The Confederacy of Independent Systems, or simply known as the CIS or Confederacy, was a group of separatists led by former Jedi and current Sith lord, Darth Tyranus, also known as Count Dooku, who was secretly led by Darth Sidious.

The CIS was the rival of the Grand Army of the Republic during the Clone Wars, as the two had gotten into a galactic war after The Battle of Geonosis.

In the Republic Commando series, the CIS is the main antagonist, consisting of characters that are the enemies of the protagonists. In the video game, Delta Squad fight against the CIS' droid army and the Separatist Geonosians in the first few missions.